7BES

CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Uridylate kinase	polymer	281	29625.9	3	UniProt (A0A045IH65) Pfam (PF00696) UniProt (by SIFTS) (P9WHK5)	Mycobacterium tuberculosis	UK,Uridine monophosphate kinase,UMPK
2	D, E, G (A, B, C)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	3	Chemie (UDP)
3	F, H (B, C)	URIDINE 5'-TRIPHOSPHATE	non-polymer		484.1	2	Chemie (UTP)

Sequence modifications

A, B, C: 1 - 261 (UniProt: A0A045IH65)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	88877.7
Non-Polymers*	Number of molecules	5
	Total formula weight	2180.8
All*	Total formula weight	91058.4

*Water molecules are not included.