7BEL

Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs

Summary for 7BEL

• Entry DOI: 10.2210/pdb7bel/pdb
• Descriptor: Spike glycoprotein, COVOX-45 heavy chain, COVOX-88 heavy chain, ... (10 entities in total)
• Functional Keywords: sars-cov-2, antibody, germline, v-gene, receptor-binding-domain, spike, neutralisation, protection, glycosylation, valency, viral protein/immune system, viral protein, immune system, viral protein-immune system complex
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 10
• Total formula weight: 247140.22

Authors

Zhou, D.,Zhao, Y.,Ren, J.,Stuart, D. (deposition date: 2020-12-23, release date: 2021-03-03, Last modification date: 2024-01-31)

• Primary citation: Dejnirattisai, W.,Zhou, D.,Ginn, H.M.,Duyvesteyn, H.M.E.,Supasa, P.,Case, J.B.,Zhao, Y.,Walter, T.S.,Mentzer, A.J.,Liu, C.,Wang, B.,Paesen, G.C.,Slon-Campos, J.,Lopez-Camacho, C.,Kafai, N.M.,Bailey, A.L.,Chen, R.E.,Ying, B.,Thompson, C.,Bolton, J.,Fyfe, A.,Gupta, S.,Tan, T.K.,Gilbert-Jaramillo, J.,James, W.,Knight, M.,Carroll, M.W.,Skelly, D.,Dold, C.,Peng, Y.,Levin, R.,Dong, T.,Pollard, A.J.,Knight, J.C.,Klenerman, P.,Temperton, N.,Hall, D.R.,Williams, M.A.,Paterson, N.G.,Bertram, F.K.R.,Siebert, C.A.,Clare, D.K.,Howe, A.,Radecke, J.,Song, Y.,Townsend, A.R.,Huang, K.A.,Fry, E.E.,Mongkolsapaya, J.,Diamond, M.S.,Ren, J.,Stuart, D.I.,Screaton, G.R.; The antigenic anatomy of SARS-CoV-2 receptor binding domain.; Cell, 184:2183-, 2021; PubMed: 33756110; DOI: 10.1016/j.cell.2021.02.032

Experimental method

X-RAY DIFFRACTION (2.53 Å)