7BEL
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R, X | Spike glycoprotein | polymer | 205 | 23150.9 | 2 | UniProt (P0DTC2) Pfam (PF09408) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein |
2 | A, C | COVOX-45 heavy chain | polymer | 226 | 24187.2 | 2 | Homo sapiens | ||
3 | H, E | COVOX-88 heavy chain | polymer | 245 | 25853.1 | 2 | Homo sapiens | ||
4 | L, F | COVOX-88 light chain | polymer | 229 | 24278.9 | 2 | Homo sapiens | ||
5 | B, D | COVOX-45 light chain | polymer | 227 | 24671.3 | 2 | Homo sapiens | ||
6 | G, I | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
7 | R, X | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
8 | R | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
9 | R, X | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
10 | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
R, X: 333 - 528 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Glu 324 | - | expression tag |
Thr 325 | - | expression tag |
Gly 326 | - | expression tag |
His 327 | - | expression tag |
His 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
His 332 | - | expression tag |
Lys 527 | Pro 527 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 244282.6 | |
Branched | Number of molecules | 2 |
Total formula weight | 2145.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 711.6 | |
All* | Total formula weight | 247140.2 |