7BE6

Structure of DDR1 receptor tyrosine kinase in complex with inhibitor SR159

7BE6 の概要

• エントリーDOI: 10.2210/pdb7be6/pdb
• 分子名称: Epithelial discoidin domain-containing receptor 1, 1,2-ETHANEDIOL, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: ddr1 receptor tyrosine kinase, kinase inhibitor, structure-based design, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37043.43

構造登録者

Pinkas, D.M.,Bufton, J.C.,Roehm, S.,Joerger, A.C.,Knapp, S.,Bullock, A.N.,Structural Genomics Consortium (SGC) (登録日: 2020-12-22, 公開日: 2021-03-03, 最終更新日: 2024-01-31)

• 主引用文献: Rohm, S.,Berger, B.T.,Schroder, M.,Chatterjee, D.,Mathea, S.,Joerger, A.C.,Pinkas, D.M.,Bufton, J.C.,Tjaden, A.,Kovooru, L.,Kudolo, M.,Pohl, C.,Bullock, A.N.,Muller, S.,Laufer, S.,Knapp, S.; Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.; J.Med.Chem., 64:13451-13474, 2021; PubMed: 34506142; DOI: 10.1021/acs.jmedchem.1c00868

実験手法

X-RAY DIFFRACTION (1.87081933411 Å)