7BDE
HUMAN BCL6 BTB-DOMAIN IN COMPLEX WITH GSK137
Summary for 7BDE
Entry DOI | 10.2210/pdb7bde/pdb |
Descriptor | Isoform 2 of B-cell lymphoma 6 protein, 5-[(5S,7R)-3-fluoranyl-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl]quinolin-2-amine, GLYCEROL, ... (5 entities in total) |
Functional Keywords | btb domain, b-cell lymphoma, transcriptional repression transcription, inhibitor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16101.44 |
Authors | Somers, D.O. (deposition date: 2020-12-21, release date: 2021-07-28, Last modification date: 2024-05-01) |
Primary citation | Pearce, A.C.,Bamford, M.J.,Barber, R.,Bridges, A.,Convery, M.A.,Demetriou, C.,Evans, S.,Gobbetti, T.,Hirst, D.J.,Holmes, D.S.,Hutchinson, J.P.,Jayne, S.,Lezina, L.,McCabe, M.T.,Messenger, C.,Morley, J.,Musso, M.C.,Scott-Stevens, P.,Manso, A.S.,Schofield, J.,Slocombe, T.,Somers, D.,Walker, A.L.,Wyce, A.,Zhang, X.P.,Wagner, S.D. GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice. J.Biol.Chem., 297:100928-100928, 2021 Cited by PubMed: 34274316DOI: 10.1016/j.jbc.2021.100928 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.044 Å) |
Structure validation
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