7BCS
ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation.
Summary for 7BCS
Entry DOI | 10.2210/pdb7bcs/pdb |
Related | 7BCQ |
EMDB information | 12142 |
Descriptor | Neutral amino acid transporter B(0), (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid (2 entities in total) |
Functional Keywords | solute carrier transporter, membrane protein, homology modeling, cancer metabolism, glutamine deprivation, cryo-em |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 170850.70 |
Authors | Garibsingh, R.A.,Ndaru, E.,Garaeva, A.A.,Shi, Y.,Zielewicz, L.,Bonomi, M.,Slotboom, D.J.,Paulino, C.,Grewer, C.,Schlessinger, A. (deposition date: 2020-12-21, release date: 2021-09-22, Last modification date: 2024-07-10) |
Primary citation | Garibsingh, R.A.,Ndaru, E.,Garaeva, A.A.,Shi, Y.,Zielewicz, L.,Zakrepine, P.,Bonomi, M.,Slotboom, D.J.,Paulino, C.,Grewer, C.,Schlessinger, A. Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34507995DOI: 10.1073/pnas.2104093118 PDB entries with the same primary citation |
Experimental method |
Structure validation
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