7BCS

ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001618	molecular_function	virus receptor activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006865	biological_process	amino acid transport
A	0006868	biological_process	glutamine transport
A	0009925	cellular_component	basal plasma membrane
A	0010585	biological_process	glutamine secretion
A	0015171	molecular_function	amino acid transmembrane transporter activity
A	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
A	0015183	molecular_function	L-aspartate transmembrane transporter activity
A	0015186	molecular_function	L-glutamine transmembrane transporter activity
A	0015194	molecular_function	L-serine transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015297	molecular_function	antiporter activity
A	0015804	biological_process	neutral amino acid transport
A	0015825	biological_process	L-serine transport
A	0016020	cellular_component	membrane
A	0022834	molecular_function	ligand-gated channel activity
A	0030218	biological_process	erythrocyte differentiation
A	0038023	molecular_function	signaling receptor activity
A	0042470	cellular_component	melanosome
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0070207	biological_process	protein homotrimerization
A	0140009	biological_process	L-aspartate import across plasma membrane
A	0150104	biological_process	transport across blood-brain barrier
A	1903803	biological_process	L-glutamine import across plasma membrane
B	0001618	molecular_function	virus receptor activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006865	biological_process	amino acid transport
B	0006868	biological_process	glutamine transport
B	0009925	cellular_component	basal plasma membrane
B	0010585	biological_process	glutamine secretion
B	0015171	molecular_function	amino acid transmembrane transporter activity
B	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
B	0015183	molecular_function	L-aspartate transmembrane transporter activity
B	0015186	molecular_function	L-glutamine transmembrane transporter activity
B	0015194	molecular_function	L-serine transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015297	molecular_function	antiporter activity
B	0015804	biological_process	neutral amino acid transport
B	0015825	biological_process	L-serine transport
B	0016020	cellular_component	membrane
B	0022834	molecular_function	ligand-gated channel activity
B	0030218	biological_process	erythrocyte differentiation
B	0038023	molecular_function	signaling receptor activity
B	0042470	cellular_component	melanosome
B	0046718	biological_process	symbiont entry into host cell
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0070207	biological_process	protein homotrimerization
B	0140009	biological_process	L-aspartate import across plasma membrane
B	0150104	biological_process	transport across blood-brain barrier
B	1903803	biological_process	L-glutamine import across plasma membrane
C	0001618	molecular_function	virus receptor activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006865	biological_process	amino acid transport
C	0006868	biological_process	glutamine transport
C	0009925	cellular_component	basal plasma membrane
C	0010585	biological_process	glutamine secretion
C	0015171	molecular_function	amino acid transmembrane transporter activity
C	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
C	0015183	molecular_function	L-aspartate transmembrane transporter activity
C	0015186	molecular_function	L-glutamine transmembrane transporter activity
C	0015194	molecular_function	L-serine transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015297	molecular_function	antiporter activity
C	0015804	biological_process	neutral amino acid transport
C	0015825	biological_process	L-serine transport
C	0016020	cellular_component	membrane
C	0022834	molecular_function	ligand-gated channel activity
C	0030218	biological_process	erythrocyte differentiation
C	0038023	molecular_function	signaling receptor activity
C	0042470	cellular_component	melanosome
C	0046718	biological_process	symbiont entry into host cell
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0070207	biological_process	protein homotrimerization
C	0140009	biological_process	L-aspartate import across plasma membrane
C	0150104	biological_process	transport across blood-brain barrier
C	1903803	biological_process	L-glutamine import across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue TJ5 A 601

Chain	Residue
A	ILE104
A	ALA429
A	ILE431
A	PRO432
A	ASP464
A	CYS467
A	THR468
A	ASN471
A	ILE231
A	SER351
A	SER352
A	SER353
A	SER354
A	ALA383
A	MET387
A	ALA428

---

site_id	AC2
Number of Residues	16
Details	binding site for residue TJ5 B 601

Chain	Residue
B	ILE104
B	ILE231
B	SER351
B	SER352
B	SER353
B	SER354
B	ALA383
B	MET387
B	ALA428
B	ALA429
B	ILE431
B	PRO432
B	ASP464
B	CYS467
B	THR468
B	ASN471

---

site_id	AC3
Number of Residues	16
Details	binding site for residue TJ5 C 601

Chain	Residue
C	ILE104
C	ILE231
C	SER351
C	SER352
C	SER353
C	SER354
C	ALA383
C	MET387
C	ALA428
C	ALA429
C	ILE431
C	PRO432
C	ASP464
C	CYS467
C	THR468
C	ASN471

---

Functional Information from PROSITE/UniProt

site_id	PS00713
Number of Residues	15
Details	NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GElLLrLLRMIIlP

Chain	Residue	Details
A	PRO92-PRO106

---

site_id	PS00714
Number of Residues	24
Details	NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PiGaTvNMDGAaLFqcVaaVFIAQ

Chain	Residue	Details
A	PRO380-GLN403

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	87
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	378
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	99
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	69
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	81
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	189
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"29872227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O59010","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---