7B8W

Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470

Summary for 7B8W

• Entry DOI: 10.2210/pdb7b8w/pdb
• Related: 5NXC
• Descriptor: LIM domain kinase 1, 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: limk1 kinase domain, inhibitor, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 146588.21

Authors

Lee, H.,Yosaatmadja, Y.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Elkins, J.M. (deposition date: 2020-12-13, release date: 2022-03-02, Last modification date: 2024-01-31)

• Primary citation: Lee, H.,Yosaatmadja, Y.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Elkins, J.M.; Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)