7B8W
Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGCFGQAIkVthretgev..........MVMK |
| Chain | Residue | Details |
| A | LEU345-LYS368 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP460 | |
| B | ASP460 | |
| C | ASP460 | |
| D | ASP460 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU345 | |
| A | LYS368 | |
| B | LEU345 | |
| B | LYS368 | |
| C | LEU345 | |
| C | LYS368 | |
| D | LEU345 | |
| D | LYS368 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER337 | |
| B | SER337 | |
| C | SER337 | |
| D | SER337 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by ROCK1 and PAK1 => ECO:0000269|PubMed:10559936, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:23633677 |
| Chain | Residue | Details |
| A | THR508 | |
| B | THR508 | |
| C | THR508 | |
| D | THR508 |
