7B8W
Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | LIM domain kinase 1 | polymer | 310 | 35994.8 | 4 | UniProt (P53667) Pfam (PF07714) In PDB | Homo sapiens (human) | LIMK-1 |
| 2 | A, B, C, D | 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide | non-polymer | 605.7 | 4 | Chemie (T3B) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 330 - 637 (UniProt: P53667)
| PDB | External Database | Details |
|---|---|---|
| Ser 328 | - | expression tag |
| Met 329 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143979.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2609.1 | |
| All* | Total formula weight | 146588.2 |
