7B8W

Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470

7B8W の概要

• エントリーDOI: 10.2210/pdb7b8w/pdb
• 関連するPDBエントリー: 5NXC
• 分子名称: LIM domain kinase 1, 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: limk1 kinase domain, inhibitor, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146588.21

構造登録者

Lee, H.,Yosaatmadja, Y.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Elkins, J.M. (登録日: 2020-12-13, 公開日: 2022-03-02, 最終更新日: 2024-01-31)

• 主引用文献: Lee, H.,Yosaatmadja, Y.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Elkins, J.M.; Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470; To Be Published,

実験手法

X-RAY DIFFRACTION (2.8 Å)