7B7G

BAZ2A bromodomain in complex with compounds MS04 and B11

Summary for 7B7G

• Entry DOI: 10.2210/pdb7b7g/pdb
• Related: 7B7B
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2A, 5-ethyl-2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazole, 1-[1-(3,5-dimethoxyphenyl)piperidin-4-yl]-2,3-dimethyl-guanidine, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 12897.54

Authors

Dalle Vedove, A.,Cazzanelli, G.,Sedykh, M.,Caflisch, A.,Lolli, G. (deposition date: 2020-12-10, release date: 2021-10-20, Last modification date: 2024-01-31)

• Primary citation: Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G.; Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing.; Acs Med.Chem.Lett., 13:1434-1443, 2022; PubMed: 36105334; DOI: 10.1021/acsmedchemlett.2c00173

Experimental method

X-RAY DIFFRACTION (1.428 Å)