7B49

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ

7B49 の概要

• エントリーDOI: 10.2210/pdb7b49/pdb
• 関連するPDBエントリー: 6ZNC 7B46 7B47 7B48 7B4A 7B4B 7B4C 7B4D 7B4E 7B4F 7B4G 7B4H 7B4N
• 分子名称: Cellular tumor antigen p53, DNA target, ZINC ION, ... (9 entities in total)
• 機能のキーワード: p53, tumor suppressor, dna binding protein, protein dna complex, michael acceptor, michael reaction, protein-drug complex, protein-dna-drug complex, loop-sheet-helix motif, dna target, activator, transcription, hoogsteen base-pairing
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 53572.76

構造登録者

Rozenberg, H.,Degtjarik, O.,Shakked, Z. (登録日: 2020-12-02, 公開日: 2021-12-08, 最終更新日: 2024-01-31)

• 主引用文献: Degtjarik, O.,Golovenko, D.,Diskin-Posner, Y.,Abrahmsen, L.,Rozenberg, H.,Shakked, Z.; Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).; Nat Commun, 12:7057-7057, 2021; PubMed: 34862374; DOI: 10.1038/s41467-021-27142-6

実験手法

X-RAY DIFFRACTION (1.42 Å)