7B49
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cellular tumor antigen p53 | polymer | 200 | 22486.5 | 2 | UniProt (P04637) Pfam (PF00870) In PDB | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C | DNA target | polymer | 21 | 6441.1 | 1 | synthetic construct | ||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A, B | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 2 | Chemie (QN8) | |||
| 5 | A, B | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 2 | Chemie (QNN) | |||
| 6 | B, A, C | FORMIC ACID | non-polymer | 46.0 | 24 | Chemie (FMT) | |||
| 7 | B, A | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 8 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 9 | water | water | 18.0 | 498 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| His 273 | Arg 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51414.2 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 2158.6 | |
| All* | Total formula weight | 53572.8 |
