7AX4

Human TYK2 pseudokinase domain (575-869) in complex with 5-(4-Fluoro-phenyl)-2-ureido-thiophene-3-carboxylic acid amide.

Summary for 7AX4

• Entry DOI: 10.2210/pdb7ax4/pdb
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: tyk2 pseudokinase tpca-1, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 66615.62

Authors

Rowland, P. (deposition date: 2020-11-09, release date: 2021-04-14, Last modification date: 2021-06-02)

• Primary citation: Greenhough, L.A.,Clarke, G.,Phillipou, A.N.,Mazani, F.,Karamshi, B.,Rowe, S.,Rowland, P.,Messenger, C.,Haslam, C.P.,Bingham, R.P.,Craggs, P.D.; Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System.; SLAS Discov, 26:663-675, 2021; PubMed: 33783261; DOI: 10.1177/24725552211002472

Experimental method

X-RAY DIFFRACTION (2.12 Å)