7AWL

Structure of the thermostabilized EAAT1 cryst-II mutant in complex with barium and the allosteric inhibitor UCPH101

Summary for 7AWL

Entry DOI	10.2210/pdb7awl/pdb
Descriptor	Excitatory amino acid transporter 1, Neutral amino acid transporter, Excitatory amino acid transporter, Transporter protein, 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, BARIUM ION (3 entities in total)
Functional Keywords	excitatory amino acid transporter 1, human glutamate transporter, slc1a3, ion-coupling mechanism, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	57157.45
Authors	Canul-Tec, J.C.,Legrand, P.,Reyes, N. (deposition date: 2020-11-08, release date: 2021-10-13, Last modification date: 2024-01-31)
Primary citation	Canul-Tec, J.C.,Kumar, A.,Dhenin, J.,Assal, R.,Legrand, P.,Rey, M.,Chamot-Rooke, J.,Reyes, N. The ion-coupling mechanism of human excitatory amino acid transporters. Embo J., 41:e108341-e108341, 2022 Cited by PubMed: 34747040 DOI: 10.15252/embj.2021108341 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation