7AWC

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with rosiglitazone

Summary for 7AWC

Entry DOI	10.2210/pdb7awc/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), GLYCEROL, ... (4 entities in total)
Functional Keywords	pparg, steroid hormone receptor, inhibitor, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32485.69
Authors	Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-06, release date: 2020-11-25, Last modification date: 2024-01-31)
Primary citation	Willems, S.,Gellrich, L.,Chaikuad, A.,Kluge, S.,Werz, O.,Heering, J.,Knapp, S.,Lorkowski, S.,Schubert-Zsilavecz, M.,Merk, D. Endogenous vitamin E metabolites mediate allosteric PPAR gamma activation with unprecedented co-regulatory interactions. Cell Chem Biol, 28:1489-1500.e8, 2021 Cited by PubMed: 33989565 DOI: 10.1016/j.chembiol.2021.04.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation