7AWC

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with rosiglitazone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue BRL A 501

Chain	Residue
A	PHE282
A	TYR473
A	HOH648
A	CYS285
A	SER289
A	HIS323
A	TYR327
A	ILE341
A	MET364
A	HIS449
A	LEU453

---

site_id	AC2
Number of Residues	9
Details	binding site for residue GOL A 502

Chain	Residue
A	MET202
A	GLN203
A	LEU204
A	SER208
A	ASN335
A	ASP337
A	PHE347
A	LEU419
A	HOH601

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 503

Chain	Residue
A	ARG234
A	ASN335
A	LYS336

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 504

Chain	Residue
A	GLU276
A	VAL277
A	ARG280
A	HOH659
A	HOH660
A	HOH677

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 506

Chain	Residue
A	LYS336
A	ASP337
A	ARG350
A	GLU351
A	ASN424
A	HOH608
A	HOH690

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---