7AVL

Crystal structure of SOS1 in complex with compound 4

7AVL の概要

• エントリーDOI: 10.2210/pdb7avl/pdb
• 分子名称: Son of sevenless homolog 1, IMIDAZOLE, 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-phenylethyl]quinazolin-4-amine, ... (4 entities in total)
• 機能のキーワード: rasgef, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115336.94

構造登録者

Bader, G.,Kessler, D.,Wolkerstorfer, B. (登録日: 2020-11-05, 公開日: 2021-03-24, 最終更新日: 2024-01-31)

• 主引用文献: Ramharter, J.,Kessler, D.,Ettmayer, P.,Hofmann, M.H.,Gerstberger, T.,Gmachl, M.,Wunberg, T.,Kofink, C.,Sanderson, M.,Arnhof, H.,Bader, G.,Rumpel, K.,Zophel, A.,Schnitzer, R.,Bottcher, J.,O'Connell, J.C.,Mendes, R.L.,Richard, D.,Pototschnig, N.,Weiner, I.,Hela, W.,Hauer, K.,Haering, D.,Lamarre, L.,Wolkerstorfer, B.,Salamon, C.,Werni, P.,Munico-Martinez, S.,Meyer, R.,Kennedy, M.D.,Kraut, N.,McConnell, D.B.; One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.; J.Med.Chem., 64:6569-6580, 2021; PubMed: 33719426; DOI: 10.1021/acs.jmedchem.0c01949

実験手法

X-RAY DIFFRACTION (1.718 Å)