7AUA

Cryo-EM structure of human exostosin-like 3 (EXTL3) in complex with UDP

Summary for 7AUA

• Entry DOI: 10.2210/pdb7aua/pdb
• Related: 7AU2
• EMDB information: 11923 11926
• Descriptor: Exostosin-like 3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: glycosyltransferase, heparan, n-acetylglucosaminyltransferase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 206674.60

Authors

Wilson, L.F.L.,Dendooven, T.,Hardwick, S.W.,Chirgadze, D.Y.,Luisi, B.F.,Logan, D.T.,Mani, K.,Dupree, P. (deposition date: 2020-11-02, release date: 2022-05-18, Last modification date: 2022-06-15)

• Primary citation: Wilson, L.F.L.,Dendooven, T.,Hardwick, S.W.,Echevarria-Poza, A.,Tryfona, T.,Krogh, K.B.R.M.,Chirgadze, D.Y.,Luisi, B.F.,Logan, D.T.,Mani, K.,Dupree, P.; The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.; Nat Commun, 13:3314-3314, 2022; PubMed: 35676258; DOI: 10.1038/s41467-022-31048-2

Experimental method

ELECTRON MICROSCOPY (2.93 Å)