7AUA

Cryo-EM structure of human exostosin-like 3 (EXTL3) in complex with UDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Exostosin-like 3	polymer	890	101705.1	2	UniProt (O43909) Pfam (PF03016) Pfam (PF09258) In PDB	Homo sapiens (Human)	EXT-related protein 1,Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Hereditary multiple exostoses gene isolog,Multiple exostosis-like protein 3,Putative tumor suppressor protein EXTL3
2	C, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	D, F	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G81315DD)
4	A, B	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
5	A, B	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	2	Chemie (UDP)

Sequence modifications

A, B: 51 - 919 (UniProt: O43909)

PDB	External Database	Details
Ala 30	-	expression tag
Pro 31	-	expression tag
Gln 32	-	expression tag
Leu 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
Asp 40	-	expression tag
Leu 41	-	expression tag
Tyr 42	-	expression tag
Glu 43	-	expression tag
Asn 44	-	expression tag
Leu 45	-	expression tag
Tyr 46	-	expression tag
Phe 47	-	expression tag
Gln 48	-	expression tag
Gly 49	-	expression tag
Lys 50	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	203410.2
Branched	Number of molecules	4
	Total formula weight	2346.2
Non-Polymers*	Number of molecules	4
	Total formula weight	918.2
All*	Total formula weight	206674.6

*Water molecules are not included.