7AOP

Structure of NUDT15 in complex with inhibitor TH8321

Summary for 7AOP

• Entry DOI: 10.2210/pdb7aop/pdb
• Related: 7AOM
• Descriptor: Nucleotide triphosphate diphosphatase NUDT15, 2-azanyl-9-cyclohexyl-8-(2-methoxyphenyl)-3~{H}-purine-6-thione, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: nudix hydrolase, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19014.76

Authors

Rehling, D.,Zhang, S.M.,Helleday, T.,Stenmark, P. (deposition date: 2020-10-14, release date: 2021-06-02, Last modification date: 2024-01-31)

• Primary citation: Zhang, S.M.,Rehling, D.,Jemth, A.S.,Throup, A.,Landazuri, N.,Almlof, I.,Gottmann, M.,Valerie, N.C.K.,Borhade, S.R.,Wakchaure, P.,Page, B.D.G.,Desroses, M.,Homan, E.J.,Scobie, M.,Rudd, S.G.,Berglund, U.W.,Soderberg-Naucler, C.,Stenmark, P.,Helleday, T.; NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.; Cell Chem Biol, 28:1693-1702.e6, 2021; PubMed: 34192523; DOI: 10.1016/j.chembiol.2021.06.001

Experimental method

X-RAY DIFFRACTION (2.35 Å)