7AMA

IL-17A in complex with small molecule modulators

Summary for 7AMA

Entry DOI	10.2210/pdb7ama/pdb
Descriptor	Interleukin-17A, ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide (3 entities in total)
Functional Keywords	interleukin il-17a inhibitor receptor, immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	25789.28
Authors	Hakansson, M.,Kimbung, R.,Logan, D.,Walse, U.B.,de Groot, M.J.,Andrews, M.D.,Dack, K.N.,Lambert, M. (deposition date: 2020-10-08, release date: 2022-04-20, Last modification date: 2024-05-01)
Primary citation	Andrews, M.D.,Dack, K.N.,de Groot, M.J.,Lambert, M.,Sennbro, C.J.,Larsen, M.,Stahlhut, M. Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65:8828-8842, 2022 Cited by PubMed: 35767390 DOI: 10.1021/acs.jmedchem.2c00422 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation