7AHV

Anti-FIXa Fab of mim8 in complex with human FIXa

Summary for 7AHV

• Entry DOI: 10.2210/pdb7ahv/pdb
• Related: 7AHU
• Descriptor: anti-FIXa Fab of mim8 heavy chain, anti-FIXa Fab of mim8 light chain, Coagulation factor IX, ... (7 entities in total)
• Functional Keywords: fab, anti-fixa, hydrolase, mim8, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 82391.44

Authors

Johansson, E. (deposition date: 2020-09-25, release date: 2021-07-07, Last modification date: 2024-01-31)

• Primary citation: Ostergaard, H.,Lund, J.,Greisen, P.J.,Kjellev, S.,Henriksen, A.,Lorenzen, N.,Johansson, E.,Roder, G.,Rasch, M.G.,Johnsen, L.B.,Egebjerg, T.,Lund, S.,Rahbek-Nielsen, H.,Gandhi, P.S.,Lamberth, K.,Loftager, M.,Andersen, L.M.,Bonde, A.C.,Stavenuiter, F.,Madsen, D.E.,Li, X.,Holm, T.L.,Ley, C.D.,Thygesen, P.,Zhu, H.,Zhou, R.,Thorn, K.,Yang, Z.,Hermit, M.B.,Bjelke, J.R.,Hansen, B.G.,Hilden, I.; A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.; Blood, 138:1258-1268, 2021; PubMed: 34077951; DOI: 10.1182/blood.2020010331

Experimental method

X-RAY DIFFRACTION (3.11 Å)