7A6E

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Summary for 7A6E

• Entry DOI: 10.2210/pdb7a6e/pdb
• Related: 7A65 7A69 7A6C
• EMDB information: 11671
• Descriptor: Multidrug resistance protein 1, MRK16 Fab-fragment light chain, MRK16 Fab-fragment heavy chain, ... (5 entities in total)
• Functional Keywords: p-glycoprotein, mdr1, nanodisc, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 194730.43

Authors

Nosol, K.,Locher, K.P. (deposition date: 2020-08-25, release date: 2020-10-14, Last modification date: 2020-10-28)

• Primary citation: Nosol, K.,Romane, K.,Irobalieva, R.N.,Alam, A.,Kowal, J.,Fujita, N.,Locher, K.P.; Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.; Proc.Natl.Acad.Sci.USA, 117:26245-26253, 2020; PubMed: 33020312; DOI: 10.1073/pnas.2010264117

Experimental method

ELECTRON MICROSCOPY (3.6 Å)