7A6E

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006869	biological_process	lipid transport
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0009986	cellular_component	cell surface
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0045332	biological_process	phospholipid translocation
A	0046865	biological_process	terpenoid transport
A	0046943	molecular_function	carboxylic acid transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0070633	biological_process	transepithelial transport
A	0072089	biological_process	stem cell proliferation
A	0090554	molecular_function	phosphatidylcholine floppase activity
A	0090555	molecular_function	phosphatidylethanolamine flippase activity
A	0098591	cellular_component	external side of apical plasma membrane
A	0099038	molecular_function	ceramide floppase activity
A	0099040	biological_process	ceramide translocation
A	0140115	biological_process	export across plasma membrane
A	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
A	0140328	molecular_function	floppase activity
A	0140341	molecular_function	phosphatidylethanolamine floppase activity
A	0140359	molecular_function	ABC-type transporter activity
A	0150104	biological_process	transport across blood-brain barrier
A	1905039	biological_process	carboxylic acid transmembrane transport
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
A	1990962	biological_process	xenobiotic transport across blood-brain barrier
A	2001225	biological_process	regulation of chloride transport

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL

Chain	Residue	Details
A	LEU531-LEU545
A	LEU1176-LEU1190

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR197-HIS204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	249
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	216
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	58
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	236
Details	Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	289
Details	Domain: {"description":"ABC transmembrane type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	238
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---