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7A6E

Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar

Functional Information from GO Data
ChainGOidnamespacecontents
A0000086biological_processG2/M transition of mitotic cell cycle
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006805biological_processxenobiotic metabolic process
A0006869biological_processlipid transport
A0008559molecular_functionABC-type xenobiotic transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009986cellular_componentcell surface
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0031625molecular_functionubiquitin protein ligase binding
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0045332biological_processphospholipid translocation
A0046865biological_processterpenoid transport
A0046943molecular_functioncarboxylic acid transmembrane transporter activity
A0047484biological_processregulation of response to osmotic stress
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0070633biological_processtransepithelial transport
A0072089biological_processstem cell proliferation
A0090554molecular_functionphosphatidylcholine floppase activity
A0090555molecular_functionphosphatidylethanolamine flippase activity
A0098591cellular_componentexternal side of apical plasma membrane
A0099038molecular_functionceramide floppase activity
A0099040biological_processceramide translocation
A0140115biological_processexport across plasma membrane
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A0150104biological_processtransport across blood-brain barrier
A1901529biological_processpositive regulation of anion channel activity
A1905039biological_processcarboxylic acid transmembrane transport
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
A1990962biological_processxenobiotic transport across blood-brain barrier
A2001225biological_processregulation of chloride transport
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
ChainResidueDetails
ALEU531-LEU545
ALEU1176-LEU1190

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
BTYR197-HIS204

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues901
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AMET1-ASN44
ALEU138-ILE186
ASER237-ALA292
AGLU353-PHE711
AGLY778-ARG832
AGLU875-LYS934
APRO996-GLN1280

site_idSWS_FT_FI2
Number of Residues249
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ATRP45-LEU67
ATYR117-CYS137
AGLY187-PHE208
ALEU216-LEU236
AILE293-TYR316
AVAL331-ILE352
AVAL712-PHE732
ALEU757-PHE777
ALEU833-TYR853
ATRP855-VAL874
AALA935-PHE957
AVAL974-ALA995

site_idSWS_FT_FI3
Number of Residues106
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AMET68-TYR116
ATHR209-THR215
AGLY317-GLN330
ASER733-SER756
AARG958-ASP973
AGLY854

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY1070
AGLY427

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06795
ChainResidueDetails
ASER660

site_idSWS_FT_FI6
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN94
AASN99
AASN91

219869

PDB entries from 2024-05-15

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