7A69
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine
Summary for 7A69
Entry DOI | 10.2210/pdb7a69/pdb |
EMDB information | 11667 |
Descriptor | Multidrug resistance protein 1, MRK16 Fab-fragment light chain, MRK16 Fab-fragment heavy chain, ... (5 entities in total) |
Functional Keywords | p-glycoprotein, mdr1, nanodisc, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 193101.96 |
Authors | Nosol, K.,Locher, K.P. (deposition date: 2020-08-25, release date: 2020-10-21, Last modification date: 2020-10-28) |
Primary citation | Nosol, K.,Romane, K.,Irobalieva, R.N.,Alam, A.,Kowal, J.,Fujita, N.,Locher, K.P. Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc.Natl.Acad.Sci.USA, 117:26245-26253, 2020 Cited by PubMed: 33020312DOI: 10.1073/pnas.2010264117 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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