7A5Y

Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS (T8T) and Mg

Summary for 7A5Y

• Entry DOI: 10.2210/pdb7a5y/pdb
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: triphosphohydrolase, metallo-enzyme, binuclear, hd, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 494721.91

Authors

Morris, E.R.,Kunzelmann, S.,Caswell, S.J.,Purkiss, A.,Taylor, I.A. (deposition date: 2020-08-24, release date: 2021-05-26, Last modification date: 2024-01-31)

• Primary citation: Morris, E.R.,Kunzelmann, S.,Caswell, S.J.,Purkiss, A.G.,Kelly, G.,Taylor, I.A.; Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R p - and S p -dNTP alpha S Diastereomers.; Biochemistry, 60:1682-1698, 2021; PubMed: 33988981; DOI: 10.1021/acs.biochem.0c00944

Experimental method

X-RAY DIFFRACTION (2.29 Å)