7A5L

tructure of DYRK1A in complex with compound 24

Summary for 7A5L

Entry DOI	10.2210/pdb7a5l/pdb
Related	7a4o 7a4r 7a4s 7a4w 7a4z 7a51 7a52 7a53 7a55 7a5b 7a5d
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-[2-methyl-4-(thiophen-3-ylmethoxy)-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]pyridin-2-amine, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	serine/threonine-protein kinase, phosphoprotein, kinase, sbdd, fbld, small molecule inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42019.98
Authors	Dokurno, P.,Surgenor, A.E.,Hubbard, R.E. (deposition date: 2020-08-21, release date: 2021-06-30, Last modification date: 2024-01-31)
Primary citation	Lee Walmsley, D.,Murray, J.B.,Dokurno, P.,Massey, A.J.,Benwell, K.,Fiumana, A.,Foloppe, N.,Ray, S.,Smith, J.,Surgenor, A.E.,Edmonds, T.,Demarles, D.,Burbridge, M.,Cruzalegui, F.,Kotschy, A.,Hubbard, R.E. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64:8971-8991, 2021 Cited by PubMed: 34143631 DOI: 10.1021/acs.jmedchem.1c00024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation