7A4R
Structure of DYRK1A in complex with compound 1
Summary for 7A4R
Entry DOI | 10.2210/pdb7a4r/pdb |
Related | 7a4o |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 2-amino-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | serine/threonine-protein kinase, phosphoprotein, kinase, sbdd, fbld, small molecule inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 82685.64 |
Authors | Dokurno, P.,Surgenor, A.E.,Hubbard, R.E. (deposition date: 2020-08-20, release date: 2021-06-30, Last modification date: 2024-01-31) |
Primary citation | Lee Walmsley, D.,Murray, J.B.,Dokurno, P.,Massey, A.J.,Benwell, K.,Fiumana, A.,Foloppe, N.,Ray, S.,Smith, J.,Surgenor, A.E.,Edmonds, T.,Demarles, D.,Burbridge, M.,Cruzalegui, F.,Kotschy, A.,Hubbard, R.E. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64:8971-8991, 2021 Cited by PubMed: 34143631DOI: 10.1021/acs.jmedchem.1c00024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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