7A4S
Structure of DYRK1A in complex with compound 2
Summary for 7A4S
| Entry DOI | 10.2210/pdb7a4s/pdb |
| Related | 7a4o 7a4r |
| Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 7-chlorothieno[3,2-c]pyridin-4-amine (3 entities in total) |
| Functional Keywords | serine/threonine-protein kinase, phosphoprotein, kinase, sbdd, fbld, small molecule inhibitor, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 41831.78 |
| Authors | Dokurno, P.,Surgenor, A.E.,Hubbard, R.E. (deposition date: 2020-08-20, release date: 2021-06-30, Last modification date: 2024-01-31) |
| Primary citation | Lee Walmsley, D.,Murray, J.B.,Dokurno, P.,Massey, A.J.,Benwell, K.,Fiumana, A.,Foloppe, N.,Ray, S.,Smith, J.,Surgenor, A.E.,Edmonds, T.,Demarles, D.,Burbridge, M.,Cruzalegui, F.,Kotschy, A.,Hubbard, R.E. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64:8971-8991, 2021 Cited by PubMed: 34143631DOI: 10.1021/acs.jmedchem.1c00024 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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