7A3L
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A241
Summary for 7A3L
Entry DOI | 10.2210/pdb7a3l/pdb |
Related | 6EOP |
Descriptor | Dipeptidyl peptidase 8, 2-ethyl-2-methanoyl-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]butanamide, GLYCEROL, ... (6 entities in total) |
Functional Keywords | dpp8, protease, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 312403.78 |
Authors | Ross, B.H.,Huber, R. (deposition date: 2020-08-18, release date: 2021-06-30, Last modification date: 2024-01-31) |
Primary citation | Carvalho, L.A.R.,Ross, B.,Fehr, L.,Bolgi, O.,Wohrle, S.,Lum, K.M.,Podlesainski, D.,Vieira, A.C.,Kiefersauer, R.,Felix, R.,Rodrigues, T.,Lucas, S.D.,Gross, O.,Geiss-Friedlander, R.,Cravatt, B.F.,Huber, R.,Kaiser, M.,Moreira, R. Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew.Chem.Int.Ed.Engl., 2022 Cited by PubMed: 36089535DOI: 10.1002/anie.202210498 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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