7A3L
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A241
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Dipeptidyl peptidase 8 | polymer | 898 | 103483.4 | 3 | UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8 |
| 2 | D, I, O (A, B, C) | 2-ethyl-2-methanoyl-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]butanamide | non-polymer | 331.5 | 3 | Chemie (QXN) | |||
| 3 | E, G, J, M, P... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 4 | F, K, L, Q (A, B, C) | trimethylamine oxide | non-polymer | 75.1 | 4 | Chemie (TMO) | |||
| 5 | H, N, S (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | T, U, V (A, B, C) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 310450.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1953.7 | |
| All* | Total formula weight | 312403.8 |
