7A3J

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A272

Summary for 7A3J

• Entry DOI: 10.2210/pdb7a3j/pdb
• Related: 6EOP
• Descriptor: Dipeptidyl peptidase 8, 2-ethyl-2-methanoyl-~{N}-[3-[[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide, trimethylamine oxide, ... (5 entities in total)
• Functional Keywords: dpp8, protease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 312154.57

Authors

Ross, B.H.,Huber, R. (deposition date: 2020-08-18, release date: 2021-06-30, Last modification date: 2024-01-31)

• Primary citation: Carvalho, L.A.R.,Ross, B.,Fehr, L.,Bolgi, O.,Wohrle, S.,Lum, K.M.,Podlesainski, D.,Vieira, A.C.,Kiefersauer, R.,Felix, R.,Rodrigues, T.,Lucas, S.D.,Gross, O.,Geiss-Friedlander, R.,Cravatt, B.F.,Huber, R.,Kaiser, M.,Moreira, R.; Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.; Angew.Chem.Int.Ed.Engl., 2022; PubMed: 36089535; DOI: 10.1002/anie.202210498

Experimental method

X-RAY DIFFRACTION (3 Å)