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7A3J

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, A272

Functional Information from GO Data
ChainGOidnamespacecontents
A0004177molecular_functionaminopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0016787molecular_functionhydrolase activity
A0043069biological_processnegative regulation of programmed cell death
B0004177molecular_functionaminopeptidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0006955biological_processimmune response
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0016787molecular_functionhydrolase activity
B0043069biological_processnegative regulation of programmed cell death
C0004177molecular_functionaminopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0006955biological_processimmune response
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0016787molecular_functionhydrolase activity
C0043069biological_processnegative regulation of programmed cell death
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12534281","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29382749","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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