7A3G

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, 91

Summary for 7A3G

Entry DOI	10.2210/pdb7a3g/pdb
Related	6EOP
Descriptor	Dipeptidyl peptidase 8, trimethylamine oxide, ~{N}-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-2-ethyl-2-methanoyl-butanamide, ... (8 entities in total)
Functional Keywords	dpp8, protease, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	210096.12
Authors	Ross, B.H.,Huber, R. (deposition date: 2020-08-18, release date: 2021-06-30, Last modification date: 2024-01-31)
Primary citation	Carvalho, L.A.R.,Ross, B.,Fehr, L.,Bolgi, O.,Wohrle, S.,Lum, K.M.,Podlesainski, D.,Vieira, A.C.,Kiefersauer, R.,Felix, R.,Rodrigues, T.,Lucas, S.D.,Gross, O.,Geiss-Friedlander, R.,Cravatt, B.F.,Huber, R.,Kaiser, M.,Moreira, R. Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew.Chem.Int.Ed.Engl., 2022 Cited by PubMed: 36089535 DOI: 10.1002/anie.202210498 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation