7A3G
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, 91
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Dipeptidyl peptidase 8 | polymer | 898 | 103483.4 | 2 | UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8 |
| 2 | C, E, N, P (B, A) | trimethylamine oxide | non-polymer | 75.1 | 4 | Chemie (TMO) | |||
| 3 | D, O (B, A) | ~{N}-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-2-ethyl-2-methanoyl-butanamide | non-polymer | 408.5 | 2 | Chemie (QXQ) | |||
| 4 | F, G, Q, R (B, A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | H, I, J, K, S... (B, A) | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 6 | L, W (B, A) | 1-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-3,3-diethyl-azetidine-2,4-dione | non-polymer | 406.5 | 2 | Chemie (QXT) | |||
| 7 | M, X (B, A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | Y, Z (B, A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 206966.7 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3129.4 | |
| All* | Total formula weight | 210096.1 |
