7A2A
Crystal Structure of EGFR-T790M/V948R in Complex with Spebrutinib and EAI001
Summary for 7A2A
Entry DOI | 10.2210/pdb7a2a/pdb |
Descriptor | Epidermal growth factor receptor, (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, ~{N}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide, ... (6 entities in total) |
Functional Keywords | egfr, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 77897.25 |
Authors | Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2020-08-17, release date: 2020-11-11, Last modification date: 2024-01-31) |
Primary citation | Niggenaber, J.,Heyden, L.,Grabe, T.,Muller, M.P.,Lategahn, J.,Rauh, D. Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. Acs Med.Chem.Lett., 11:2484-2490, 2020 Cited by PubMed: 33335671DOI: 10.1021/acsmedchemlett.0c00472 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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