7YIV
The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH
Summary for 7YIV
Entry DOI | 10.2210/pdb7yiv/pdb |
Descriptor | Alkaline phosphatase, tissue-nonspecific isozyme, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | alkaline phosphatase, bone mineralization, catalytic network, hypophosphatasia, structural biology, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 468052.86 |
Authors | |
Primary citation | Yu, Y.,Rong, K.,Yao, D.,Zhang, Q.,Cao, X.,Rao, B.,Xia, Y.,Lu, Y.,Shen, Y.,Yao, Y.,Xu, H.,Ma, P.,Cao, Y.,Qin, A. The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase. Nat Commun, 14:4048-4048, 2023 Cited by PubMed: 37422472DOI: 10.1038/s41467-023-39833-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.18 Å) |
Structure validation
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