7XI9
Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form)
This is a non-PDB format compatible entry.
Summary for 7XI9
Entry DOI | 10.2210/pdb7xi9/pdb |
EMDB information | 33200 |
Descriptor | DNA (cytosine-5)-methyltransferase 1, DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), ... (6 entities in total) |
Functional Keywords | dna methyltransferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 151156.98 |
Authors | Onoda, H.,Kikuchi, A.,Kori, S.,Yoshimi, S.,Yamagata, A.,Arita, K. (deposition date: 2022-04-12, release date: 2022-11-30, Last modification date: 2024-07-03) |
Primary citation | Kikuchi, A.,Onoda, H.,Yamaguchi, K.,Kori, S.,Matsuzawa, S.,Chiba, Y.,Tanimoto, S.,Yoshimi, S.,Sato, H.,Yamagata, A.,Shirouzu, M.,Adachi, N.,Sharif, J.,Koseki, H.,Nishiyama, A.,Nakanishi, M.,Defossez, P.A.,Arita, K. Structural basis for activation of DNMT1. Nat Commun, 13:7130-7130, 2022 Cited by PubMed: 36414620DOI: 10.1038/s41467-022-34779-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.52 Å) |
Structure validation
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