7WLL

CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ)

Summary for 7WLL

• Entry DOI: 10.2210/pdb7wll/pdb
• EMDB information: 32587
• Descriptor: Voltage-dependent T-type calcium channel subunit alpha-1I, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... (6 entities in total)
• Functional Keywords: cav3.3, pmz-bound, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 256496.82

Authors

He, L.,Yu, Z.,Dong, Y.,Chen, Q.,Zhao, Y. (deposition date: 2022-01-13, release date: 2022-05-04, Last modification date: 2022-05-25)

• Primary citation: He, L.,Yu, Z.,Geng, Z.,Huang, Z.,Zhang, C.,Dong, Y.,Gao, Y.,Wang, Y.,Chen, Q.,Sun, L.,Ma, X.,Huang, B.,Wang, X.,Zhao, Y.; Structure, gating, and pharmacology of human Ca V 3.3 channel.; Nat Commun, 13:2084-2084, 2022; PubMed: 35440630; DOI: 10.1038/s41467-022-29728-0

Experimental method

ELECTRON MICROSCOPY (3.6 Å)