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7WLL

CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Voltage-dependent T-type calcium channel subunit alpha-1Ipolymer2223245373.01UniProt (Q9P0X4)
Pfam (PF00520)
Pfam (PF08016)
Homo sapiens (human)Voltage-gated calcium channel subunit alpha Cav3.3,Ca(v)3.3
2B
(A)
3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-onenon-polymer461.51Chemie (1II)
3C, D, E, F, K...
(A)
1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.19Chemie (3PE)
4G, H
(A)
CALCIUM IONnon-polymer40.12Chemie (CA)
5I, L, M, O, P...
(A)
CHOLESTEROL HEMISUCCINATEnon-polymer486.77Chemie (Y01)
6J, N
(A)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight245373.0
Non-Polymers*Number of molecules21
Total formula weight11123.8
All*Total formula weight256496.8
*Water molecules are not included.

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PDB entries from 2025-08-27

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