7WLL

CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005891	cellular_component	voltage-gated calcium channel complex
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0008331	molecular_function	high voltage-gated calcium channel activity
A	0016020	cellular_component	membrane
A	0019228	biological_process	neuronal action potential
A	0030431	biological_process	sleep
A	0034702	cellular_component	monoatomic ion channel complex
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098703	biological_process	calcium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1252
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-ASN78
A	GLU1432-THR1485
A	ARG1544-LEU1556
A	LEU1608-ASN1621
A	LYS1731-ARG2223
A	LYS142-ASP148
A	VAL192-ASN211
A	THR399-LYS640
A	ASP698-ASN702
A	VAL754-THR764
A	GLU863-ILE1166
A	GLY1231-ASP1244
A	VAL1295-LYS1304

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255

Chain	Residue	Details
A	PRO79-TYR99

---

site_id	SWS_FT_FI3
Number of Residues	441
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLN100-ASP120
A	GLU1507-CYS1522
A	PRO1578-ILE1583
A	LYS1643-TYR1709
A	LEU169-ASN173
A	GLY233-TYR377
A	HIS662-ASN676
A	GLN722-VAL729
A	CYS786-TYR841
A	ALA1188-TYR1209
A	LYS1266-ARG1272
A	GLN1326-TYR1410

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255

Chain	Residue	Details
A	PHE121-GLY141

---

site_id	SWS_FT_FI5
Number of Residues	19
Details	TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255

Chain	Residue	Details
A	THR149-ASP168

---

site_id	SWS_FT_FI6
Number of Residues	17
Details	TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000255

Chain	Residue	Details
A	LEU174-ARG191

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255

Chain	Residue	Details
A	VAL212-ALA232

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255

Chain	Residue	Details
A	PHE378-ALA398

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255

Chain	Residue	Details
A	TYR641-HIS661

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255

Chain	Residue	Details
A	VAL677-PHE697

---

site_id	SWS_FT_FI11
Number of Residues	18
Details	TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255

Chain	Residue	Details
A	PRO703-GLY721

---

site_id	SWS_FT_FI12
Number of Residues	23
Details	TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000255

Chain	Residue	Details
A	LEU730-VAL753

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255

Chain	Residue	Details
A	PHE765-GLY785

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255

Chain	Residue	Details
A	PHE842-VAL862

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000255

Chain	Residue	Details
A	ILE1167-ILE1187

---

site_id	SWS_FT_FI16
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000255

Chain	Residue	Details
A	ILE1210-PHE1230

---

site_id	SWS_FT_FI17
Number of Residues	20
Details	TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000255

Chain	Residue	Details
A	GLY1245-ALA1265

---

site_id	SWS_FT_FI18
Number of Residues	21
Details	TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000255

Chain	Residue	Details
A	VAL1273-LEU1294

---

site_id	SWS_FT_FI19
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000255

Chain	Residue	Details
A	PRO1305-VAL1325

---

site_id	SWS_FT_FI20
Number of Residues	20
Details	TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000255

Chain	Residue	Details
A	PHE1411-VAL1431

---

site_id	SWS_FT_FI21
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000255

Chain	Residue	Details
A	SER1486-LEU1506

---

site_id	SWS_FT_FI22
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000255

Chain	Residue	Details
A	ASN1523-LEU1543

---

site_id	SWS_FT_FI23
Number of Residues	20
Details	TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000255

Chain	Residue	Details
A	ALA1557-LEU1577

---

site_id	SWS_FT_FI24
Number of Residues	23
Details	TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000255

Chain	Residue	Details
A	ILE1584-ALA1607

---

site_id	SWS_FT_FI25
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000255

Chain	Residue	Details
A	LEU1622-GLY1642

---

site_id	SWS_FT_FI26
Number of Residues	20
Details	TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000255

Chain	Residue	Details
A	PHE1710-MET1730

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	SITE: Calcium ion selectivity and permeability => ECO:0000250

Chain	Residue	Details
A	GLU357
A	GLU821
A	ASP1380
A	ASP1678

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0Y8

Chain	Residue	Details
A	SER1058

---

site_id	SWS_FT_FI29
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN173
A	ASN244
A	ASN311
A	ASN1342
A	ASN1345

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