7WL4

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50

Summary for 7WL4

• Entry DOI: 10.2210/pdb7wl4/pdb
• Descriptor: Bromodomain-containing protein 4, ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide (3 entities in total)
• Functional Keywords: bromodomain, brd4(1), inhibitor, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 69019.39

Authors

Zhang, C.,Wang, C.,Li, W.,Zhang, Y.,Xu, Y.,Sun, L. (deposition date: 2022-01-12, release date: 2022-08-10, Last modification date: 2023-11-29)

• Primary citation: Li, W.,Zhang, C.,Zhang, H.E.,Dong, R.,Liu, J.Y.,Wang, C.M.,Wang, M.,Wang, Y.W.,Wang, C.,Zhang, Y.,Shi, L.,Xu, Y.,Sun, L.P.; Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors.; Bioorg.Chem., 127:105917-105917, 2022; PubMed: 35738217; DOI: 10.1016/j.bioorg.2022.105917

Experimental method

X-RAY DIFFRACTION (1.82 Å)