7VQT
Crystal structure of LSD1 in complex with compound 5
Summary for 7VQT
Entry DOI | 10.2210/pdb7vqt/pdb |
Descriptor | Lysine-specific histone demethylase 1A, GLYCEROL, L(+)-TARTARIC ACID, ... (5 entities in total) |
Functional Keywords | demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 75932.31 |
Authors | Niwa, H.,Koda, Y.,Sato, S.,Yamamoto, H.,Koyama, H.,Umehara, T. (deposition date: 2021-10-20, release date: 2022-06-01, Last modification date: 2023-11-29) |
Primary citation | Koda, Y.,Sato, S.,Yamamoto, H.,Niwa, H.,Watanabe, H.,Watanabe, C.,Sato, T.,Nakamura, K.,Tanaka, A.,Shirouzu, M.,Honma, T.,Fukami, T.,Koyama, H.,Umehara, T. Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13:848-854, 2022 Cited by PubMed: 35586426DOI: 10.1021/acsmedchemlett.2c00120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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