7V3S
Crystal structure of CMET in complex with a novel inhibitor
Summary for 7V3S
Entry DOI | 10.2210/pdb7v3s/pdb |
Descriptor | Hepatocyte growth factor receptor, ~{N}1'-[3-fluoranyl-4-(10~{H}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{N}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (3 entities in total) |
Functional Keywords | transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36548.07 |
Authors | Su, H.X.,Liu, Q.F.,Chen, T.T.,Li, M.J.,Xu, Y.C. (deposition date: 2021-08-11, release date: 2022-08-17, Last modification date: 2023-11-29) |
Primary citation | Zhan, Z.,Ji, Y.,Su, H.,Fang, C.,Peng, X.,Liu, Q.,Dai, Y.,Lin, D.,Xu, Y.,Ai, J.,Duan, W. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase J.Med.Chem., 66:220-234, 2023 Cited by DOI: 10.1021/acs.jmedchem.2c00962PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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