7V29
Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor
Summary for 7V29
Entry DOI | 10.2210/pdb7v29/pdb |
Descriptor | Fibroblast growth factor receptor 4, N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, dual-warhead, fibroblast growth factor receptor 4, covalent, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71131.91 |
Authors | Chen, X.J.,Jiang, L.Y.,Dai, S.Y.,Qu, L.Z.,Chen, Y.H. (deposition date: 2021-08-07, release date: 2022-03-30, Last modification date: 2023-11-29) |
Primary citation | Chen, X.,Li, H.,Lin, Q.,Dai, S.,Yue, S.,Qu, L.,Li, M.,Guo, M.,Wei, H.,Li, J.,Jiang, L.,Xu, G.,Chen, Y. Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem, 5:36-36, 2022 Cited by PubMed: 36697897DOI: 10.1038/s42004-022-00657-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.983 Å) |
Structure validation
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