7UW2
Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with UAB116 and coactivator peptide GRIP-1
Summary for 7UW2
Entry DOI | 10.2210/pdb7uw2/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-8-{3-[(2S)-butan-2-yl]-2-(3-methylbutyl)cyclohex-2-en-1-ylidene}-3,7-dimethylocta-2,4,6-trienoic acid, ... (4 entities in total) |
Functional Keywords | retinoid x receptor, retinoid x receptor alpha, ligand binding domain, coactivator complex, inhibitor complex, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 28806.47 |
Authors | Chattopadhyay, D.,Yang, Z.,Atigadda, V. (deposition date: 2022-05-02, release date: 2023-03-15, Last modification date: 2023-10-25) |
Primary citation | Atigadda, V.R.,Kashyap, M.P.,Yang, Z.,Chattopadhyay, D.,Melo, N.,Sinha, R.,Belyaeva, O.V.,Chou, C.F.,Chang, P.L.,Kedishvili, N.Y.,Grubbs, C.J.,Renfrow, M.B.,Muccio, D.D.,Elmets, C.A.,Athar, M. Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers. J.Med.Chem., 65:14409-14423, 2022 Cited by PubMed: 36318154DOI: 10.1021/acs.jmedchem.2c00735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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