7UCG
Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24
Summary for 7UCG
Entry DOI | 10.2210/pdb7ucg/pdb |
EMDB information | 26443 |
Descriptor | Envelope glycoprotein gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose, BG24 CDRH2-v2 Fab heavy chain, ... (10 entities in total) |
Functional Keywords | broadly neutralizing antibody, bnab, hiv-1, cd4 binding site, vh1-2, vrc01-class, antiviral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 18 |
Total formula weight | 534873.77 |
Authors | Barnes, C.O.,Bjorkman, P.J. (deposition date: 2022-03-16, release date: 2022-08-17, Last modification date: 2022-09-07) |
Primary citation | Barnes, C.O.,Schoofs, T.,Gnanapragasam, P.N.P.,Golijanin, J.,Huey-Tubman, K.E.,Gruell, H.,Schommers, P.,Suh-Toma, N.,Lee, Y.E.,Cetrulo Lorenzi, J.C.,Piechocka-Trocha, A.,Scheid, J.F.,West Jr., A.P.,Walker, B.D.,Seaman, M.S.,Klein, F.,Nussenzweig, M.C.,Bjorkman, P.J. A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8:eabp8155-eabp8155, 2022 Cited by PubMed: 35960796DOI: 10.1126/sciadv.abp8155 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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