7UCG
Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M (B, A, M) | Envelope glycoprotein gp41 | polymer | 153 | 17104.5 | 3 | UniProt (Q202J5) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, H, N (D, C, N) | BG24 CDRH2-v2 Fab heavy chain | polymer | 234 | 25498.6 | 3 | Homo sapiens | ||
| 3 | C, I, O (E, F, O) | BG24 light chain | polymer | 205 | 21925.2 | 3 | Homo sapiens | ||
| 4 | D, J, P (G, I, P) | Envelope glycoprotein gp160 | polymer | 507 | 57000.0 | 3 | UniProt (Q202J5) | Human immunodeficiency virus 1 | Env polyprotein |
| 5 | E, K, Q (H, J, Q) | 10-1074 Fab heavy chain | polymer | 243 | 26389.5 | 3 | Homo sapiens | ||
| 6 | F, L, R (L, K, R) | 10-1074 light chain | polymer | 216 | 23708.3 | 3 | Homo sapiens | ||
| 7 | AA, CA, DA, EA, GA... (a, c, d, e, g...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 21 | In PDB GlyTouCan (G42666HT) | |||
| 8 | FA, NA, X (f, n, X) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 9 | BA, JA, RA (b, j, r) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 3 | In PDB GlyTouCan (G07617FP) | |||
| 10 | AB, BB, CB, DB, EB... (I, P, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) |
Sequence modifications
B, A, M: 514 - 664 (UniProt: Q202J5)
G, I, P: 27 - 505 (UniProt: Q202J5)
| PDB | External Database | Details |
|---|---|---|
| Ala 512 | - | expression tag |
| Val 513 | - | expression tag |
| Met 535 | Ile 530 | conflict |
| Pro 559 | Ile 554 | conflict |
| Cys 605 | Ala 600 | conflict |
| Glu 648 | Asp 643 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Asp -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Arg 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Cys 5 | - | expression tag |
| Val 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Val 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Val 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ile 21 | - | expression tag |
| His 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Phe 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Gly 28 | Val 29 | conflict |
| Ala 29 | Val 30 | conflict |
| Glu 30 | Gly 31 | conflict |
| Arg 66 | His 67 | conflict |
| Asn 295 | Lys 300 | conflict |
| Trp 316 | Thr 319 | conflict |
| Asn 384 | Asp 388 | conflict |
| Cys 498 | Ser 496 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 514878.2 | |
| Branched | Number of molecules | 27 |
| Total formula weight | 15350.2 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 4645.4 | |
| All* | Total formula weight | 534873.8 |
