7UCG
Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A, M | Envelope glycoprotein gp41 | polymer | 153 | 17104.5 | 3 | UniProt (Q202J5) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
2 | D, C, N | BG24 CDRH2-v2 Fab heavy chain | polymer | 234 | 25498.6 | 3 | Homo sapiens | ||
3 | E, F, O | BG24 light chain | polymer | 205 | 21925.2 | 3 | Homo sapiens | ||
4 | G, I, P | Envelope glycoprotein gp160 | polymer | 507 | 57000.0 | 3 | UniProt (Q202J5) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
5 | H, J, Q | 10-1074 Fab heavy chain | polymer | 243 | 26389.5 | 3 | Homo sapiens | ||
6 | L, K, R | 10-1074 light chain | polymer | 216 | 23708.3 | 3 | Homo sapiens | ||
7 | a, c, d, e, g... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 21 | In PDB GlyTouCan (G42666HT) | |||
8 | f, n, X | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
9 | b, j, r | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 3 | In PDB GlyTouCan (G07617FP) | |||
10 | I, P, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) |
Sequence modifications
B, A, M: 514 - 664 (UniProt: Q202J5)
G, I, P: 27 - 505 (UniProt: Q202J5)
PDB | External Database | Details |
---|---|---|
Ala 512 | - | expression tag |
Val 513 | - | expression tag |
Met 535 | Ile 530 | conflict |
Pro 559 | Ile 554 | conflict |
Cys 605 | Ala 600 | conflict |
Glu 648 | Asp 643 | conflict |
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Lys 0 | - | expression tag |
Arg 1 | - | expression tag |
Gly 2 | - | expression tag |
Leu 3 | - | expression tag |
Cys 4 | - | expression tag |
Cys 5 | - | expression tag |
Val 6 | - | expression tag |
Leu 7 | - | expression tag |
Leu 8 | - | expression tag |
Leu 9 | - | expression tag |
Cys 10 | - | expression tag |
Gly 11 | - | expression tag |
Ala 12 | - | expression tag |
Val 13 | - | expression tag |
Phe 14 | - | expression tag |
Val 15 | - | expression tag |
Ser 16 | - | expression tag |
Pro 17 | - | expression tag |
Ser 18 | - | expression tag |
Gln 19 | - | expression tag |
Glu 20 | - | expression tag |
Ile 21 | - | expression tag |
His 22 | - | expression tag |
Ala 23 | - | expression tag |
Arg 24 | - | expression tag |
Phe 25 | - | expression tag |
Arg 26 | - | expression tag |
Gly 28 | Val 29 | conflict |
Ala 29 | Val 30 | conflict |
Glu 30 | Gly 31 | conflict |
Arg 66 | His 67 | conflict |
Asn 295 | Lys 300 | conflict |
Trp 316 | Thr 319 | conflict |
Asn 384 | Asp 388 | conflict |
Cys 498 | Ser 496 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 18 |
Total formula weight | 514878.2 | |
Branched | Number of molecules | 27 |
Total formula weight | 15350.2 | |
Non-Polymers* | Number of molecules | 21 |
Total formula weight | 4645.4 | |
All* | Total formula weight | 534873.8 |